Sunday, January 27, 2008

Are we about to witness first synthetic life?

Scientists have built the first synthetic genome by stringing together 147 pages of letters representing the building blocks of DNA.

This is scary stuff from the realms of science fiction. But researches say that within months we can see custom designed organisms, referred to as biological robots. The proposed use is to produce ethanol for biofuel use as well as producing other chemicals in applications we haven’t thought of yet.

Producing biofuels is an immediate and important application because one of the downsides of using food crops as biofuel production is that it drives up food prices.

The technical process involves using yeast to stitch together four long strands of DNA into the genome of a bacterium called Mycoplasma genitalium. They said it's more than an order of magnitude longer than any previous synthetic DNA creation. The actual building blocks of DNA: Adenine, Cytosine, Thymine and Guanine, are rearranged and linked together to create never-before-seen organisms that will do their bidding.

The next step is to inject this synthetic strand into a cell, sit back and let it multiply.

Just a few years ago this process of synthesizing and linking together these building blocks was impossible. Now, the possibilities seem endless. By linking together millions of base pairs, biomedical scientists can create much more complex organisms.

Some ideas I would like to see this science used for is to create organisms that would eat petroleum to clean up oil spills, another could attack rogue human cells to control cancer and other diseases if not stop them completely, organisms to break down waste products in our water systems to purify our drinking water, organisms to neutralize or eliminate the E. coli bacterium plaguing our food supply, organisms to repair human tissue, the applications are almost endless.

The scary part of this new field is how future scientists handle this knowledge. There always seems to be some ill-intentioned person or even well-meaning person whose experiments go awry and will create something monstrous. Regulation and security is of the utmost importance. Already synthetic biologists are planning to scale up from the simplest organisms to the most complex: human beings. This thinking, in my opinion is a bit premature, but it is better to have rules in place before it happens.

Currently, synthetic biologists follow the National Institutes of Health's recombinant DNA guidelines, which were penned in 1974 for the first experiments in genetic manipulation. Accepted by NIH and industry scientists alike, the rules instruct researchers on how to safely handle engineered organisms in the lab. If they want to release a synthetic organism into the environment, it would be evaluated for safety by the Environmental Protection Agency.

Manmade biological forms can do unexpected things so we need to create a safeguard, perhaps an army of synthetic robots whose purpose is to destroy the offending organism.

New terms are entering into our language, and to help explain these terms here is a Scientific American article on synthetic biology, and a Live Science article on biological robots.

The full implications of creating synthetic life are as yet unknown for the future of mankind, but rest assured Hollywood will continue to come up with creative ways to exploit any fear surrounding it.

I think we should view this latest development as a step forward in helping us clean up after ourselves and keep our environment as healthy as possible.

It will be interesting to hear viewpoints from religious leaders.

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